Oncodheep
Contact Us

For more information. Please complete this form.

Name
Email
Mobile Number
Message
Services
Home | Services
Bone malignancies ?

Bone malignancies can be primary or secondary. Here is an overview of their classification and treatment modalities:

These originate in the bone and include:

  • Osteosarcoma (most common in adolescents and young adults)

  • Ewing’s Sarcoma (common in children and young adults)

  • Chondrosarcoma (more frequent in older adults)

  • Fibrosarcoma, Chordoma, and others (rarer types)

Secondary Bone Malignancies (Metastatic Bone Disease)

  • More common than primary bone cancers.

  • Common primaries include breast, prostate, lung, thyroid, and renal cancers.

  • Metastases typically affect the axial skeleton (spine, pelvis, ribs).

Treatment Modalities

Surgery

For Primary Bone Cancers:

  • Limb-sparing surgery: Used in most cases of osteosarcoma or Ewing’s sarcoma.

  • Amputation: Rare, reserved for extensive tumors.

  • Curettage and bone grafting: For low-grade tumors like giant cell tumors.

For Metastatic Disease:

  • Surgical stabilization for fractures or impending fractures.

  • Spinal decompression for cord compression.

Radiotherapy

External Beam Radiotherapy (EBRT):

  • Definitive:For radiosensitive tumors like Ewing’s sarcoma.

  • PalliativeRelieves pain and prevents fractures in metastatic disease.

Stereotactic Body Radiotherapy (SBRT):

High precision for oligometastatic disease or spinal metastases.

Proton TherapyFor complex cases with critical structures nearby (e.g., skull base chordomas).

Radionuclide Therapy:

  • Samarium-153, Strontium-89, or Radium-223: For bone pain in metastatic disease, particularly in prostate cancer.

Chemotherapy

Primarily used for

  • Osteosarcoma: Pre- and post-surgical (neoadjuvant/adjuvant) therapy.

  • Ewing’s sarcoma: Highly responsive.

  • Common agents: Doxorubicin, cisplatin, ifosfamide, and etoposide.

Targeted Therapy

Used in metastatic and specific primary bone cancers

  • Denosumab: For giant cell tumors or prevention of skeletal-related events in metastatic bone disease.

  • Bisphosphonates: Reduce skeletal-related events and bone pain (e.g., zoledronic acid, pamidronate).

Endoscopic Therapies

Endoscopic Mucosal Resection (EMR): ): For early-stage esophageal, gastric, or colorectal cancers.

Endoscopic Submucosal Dissection (ESD): For larger lesions.

Palliative Endoscopy:

  • Stenting to relieve obstructions (e.g., esophageal or colonic stents).

  • Argon plasma coagulation for bleeding.

Immunotherapy

Limited role currently, but some sarcomas may benefit from immune checkpoint inhibitors in clinical trials.

Brachytherapy

Rarely used for bone malignancies due to anatomical challenges.

Could be considered in selected cases where localized high-dose delivery is possible (e.g., periosteal sarcomas).

Multidisciplinary Approach

Effective treatment typically involves a combination of:

  • Oncologists, Orthopedic Surgeons, Radiation Oncologists, and Palliative Care Teams.

Management is tailored based on:

  • Tumor type and grade.

  • Extent of disease (localized vs. metastatic).

  • Patient’s overall health and functional status.

Working Time
  • Mon - Tue
    -
    10:00 – 18:00
  • Wed - Thu
    -
    10:00 – 17:00
  • Fri-Sat
    -
    10:00 – 12:30
  • Sun
    -
    Closed
Need a personal health plan?
Dr.Dheepika B
Radition Oncology
+91 81221 70915
Know More
  • Have a question? call us now
    +91 81221 70915
  • Need support? Drop us an email
    info@oncodheep.com
  • We are open on
    Mon - Sat - 07:00 - 21:00
Copyright © 2024 oncodheep.com. All rights reserved.